GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
7k
c/tirzepatide·posted 2 years ago by u/sten_palacios

anyone else notice Zepbound kicking in around week 9

Question Cold Box ×7 Long Haul ×3 Clean Column ×3

Genuinely asking, not being difficult.

Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

7,393 up / 429 down95% upvoted43 commentsid 1407sc10 Dec 2023

43 comments

10 in this archive, depth 3

best — the order this archive was captured in

u/emil_barros982 points·2 years ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

replysharereportpermalink
u/incretin_ivyMOD748 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

replysharereportpermalink
u/sten_palaciosOP421 points·2 years ago

week 78 on Mounjaro and the appetite profile is genuinely different from sema

replysharereportpermalink
u/halima_boateng722 points·2 years ago

This matches the trial data. SURMOUNT-1 was 93.7% body weight at 6 weeks.

replysharereportpermalink
u/britt_okwuosa536 points·2 years ago

the dual agonism hits different and that is why people describe it differently

replysharereportpermalink
u/tove_vasquez153 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

replysharereportpermalink
u/sten_palaciosOP365 points·2 years ago

Tried both. Sema worked, tirz worked better for me, but my nausea profile was worse on tirz.

replysharereportpermalink
u/sten_palaciosOP412 points·2 years ago

Switched from sema at 2.4mg to tirz at 10mg. Different drugs, cannot compare the doses directly.

replysharereportpermalink
u/incretin_ivypharmacology174 points·2 years ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 6 weeks.

replysharereportpermalink
u/curious_panel_only244 points·2 years ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/tirzepatide
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/titration_marshalu/incretin_ivyu/quiet_moderatoru/dexa_twice_yearly
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →