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c/tirzepatide·submitted 2 years ago by u/hugo_bergstrom

24 months in and SURPASS is still the thing I get wrong

Resultsbranch of 8 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 15 months without either producing anything. What would actually settle it is 19 people measuring the…

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This branch

8 comments, started 2 years ago
u/titration_marshalMOD85 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/kian_ekstrom56 points·2 years ago

the early fullness from tirz is different, not necessarily worse

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u/elin_varga47 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/hugo_bergstromOP22 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/rania_diallo11 points·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/b12_baseline30 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/coring_the_stopper14 points·2 years ago

Is that on Mounjaro pens or research tirzepatide?

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u/sofia_nascimento61 points·2 years ago

Tracking number removed.

Yes, exactly this, and it is the bit that took me 95 weeks to accept.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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