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c/tirzepatide·submitted 2 years ago by u/tarek_kirchner

small win: GIP stopped being a problem at week 81

Questionbranch of 4 comments

Week 24 update. 25kg down from the start, reflux basically gone since about week 76. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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4 comments, started 2 years ago
u/hub_opssite staff327 points·2 years ago

My triglycerides moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/zeynep_ndiaye272 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/titration_marshalmod · c/semaglutide200 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/slow_logbook_ftw77 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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