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c/tirzepatide·submitted 5 months ago by u/hassan_nilsen

[Results] 56 weeks on 10mg, full numbers, ask me anything boring

Resultsbranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking tirzepatide against eGFR for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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5 comments, started 5 months ago
u/halima_boateng580 points·5 months ago

the dual agonism hits different and that is why people describe it differently

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u/sanne_novak467 points·5 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/halima_boateng683 points·5 months ago

the reflux from tirz is different, not necessarily worse

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u/hassan_nilsenOP0 points·5 months ago

do not crack the pen, we have been over this

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u/thyroid_tangent288 points·5 months ago

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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