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c/tirzepatide·submitted 2 months ago by u/kaia_cabrera

switched from 1.0mg to 2.5mg and the the food-noise thing got better, not worse

Questionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything. What would actually settle it is 27 people measuring the same…

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6 comments, started 2 months ago
u/quiet_moderatormod18 points·2 months ago

Switched from sema at 10mg to tirz at 2.5mg. Different drugs, cannot compare the doses directly.

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u/bastian_ekstrom8 points·2 months ago

You have restated the marketing copy. What is the actual substance here.

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u/tove_vasquez5 points·2 months ago

week 45 on Mounjaro and the appetite profile is genuinely different from sema

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u/incretin_ivypharmacology5 points·2 months ago

How long at each step before you escalated?

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u/kaia_cabreraOP2 points·2 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/quiet_moderatormod5 points·2 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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