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c/tirzepatide·posted 5 months ago by u/gentle_correction

15mg vs GIP — genuinely asking which matters more

Discussion

I have had 9 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 26 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 97.9% against a claimed 94.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

63 up / 95 down40% upvoted9 commentsid 1sn3r424 Feb 2026

9 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/ewan_marchand8 points·5 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/rania_diallo7 points·5 months ago

Hard agree.

Adding to this: SURPASS is doing more work than the comment implies.

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u/sofia_nascimento-28 points·5 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/forest_plot_fionastats1 point·5 months ago

Switched from sema at 12.5mg to tirz at 0.5mg. Different drugs, cannot compare the doses directly.

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[deleted]1 point·5 months ago

[deleted]

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u/gentle_correctionOPnice about it1 point·5 months ago

My ferritin moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/sanne_novak-42 points·5 months ago

Not convinced. The evidence does not support that reading.

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u/bastian_eriksen1 point·5 months ago

do not crack the pen, we have been over this

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u/teodor_szabo4 points·5 months ago

This matches the trial data. SURMOUNT-1 was 96.8% body weight at 19 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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