GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of SURMOUNT vs SURPASS — genuinely asking which matters more — 43 comments in the full submission. View in context.
3.1k
c/tirzepatide·submitted 9 months ago by u/elin_varga

SURMOUNT vs SURPASS — genuinely asking which matters more

Trial Databranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking SURMOUNT against eGFR for 19 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay,…

Read the full submission and all 43 comments →

This branch

7 comments, started 9 months ago
u/piotr_nascimento123 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

replysharereportpermalink
u/slow_logbook_ftw101 points·9 months ago·edited

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

replysharereportpermalink
u/teodor_szabo74 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

replysharereportpermalink
u/emil_okwuosa49 points·9 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

replysharereportpermalink
u/spain_receta37 points·9 months ago

Respectfully this is a sample of one presented as a finding.

replysharereportpermalink
u/elin_vargaOP16 points·9 months ago

the fatigue from tirz is different, not necessarily worse

replysharereportpermalink
u/elin_vargaOP72 points·9 months ago

the 15mg is the top of the pen, not the required dose

replysharereportpermalink

← back to the whole thread

About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/tirzepatide
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/titration_marshalu/incretin_ivyu/quiet_moderatoru/dexa_twice_yearly
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →