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c/tirzepatide·submitted 8 months ago by u/aurel_lindqvist

[Question] SURPASS — what am I missing here

Questionbranch of 8 comments

Right, the Mounjaro question again, but with numbers this time. I have 2 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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8 comments, started 8 months ago
u/mikkel_kimani-5 points·8 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/ewan_marchand-6 points·8 months ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 24 weeks.

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u/kaia_wojcik1 point·8 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/slow_logbook_ftw1 point·8 months ago

do not crack the pen, we have been over this

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u/titration_marshalmod · c/semaglutide1 point·8 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/sten_palacios1 point·8 months ago

the dual agonism hits different and that is why people describe it differently

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u/customs_seizure_sid1 point·8 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/kaia_wojcik1 point·8 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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