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c/tirzepatide·submitted 11 days ago by u/ferran_mensah

GIP agonism explained like i am five, please

Labbranch of 8 comments

Right, the Mounjaro question again, but with numbers this time. I have 13 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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8 comments, started 9 days ago
u/titration_marshalmod · c/semaglutide53 points·9 days ago

the 15mg is the top of the pen, not the required dose

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u/sten_palacios24 points·9 days ago·edited

the 15mg is the top of the pen, not the required dose

Adding to this: SURPASS is doing more work than the comment implies.

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u/hub_opssite staff12 points·9 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/kaia_wojcik15 points·9 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/ferran_mensahOP8 points·9 days ago

This matches the trial data. SURMOUNT-1 was 97.9% body weight at 5 weeks.

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u/nz_unfunded7 points·8 days ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/santiago_villalobos3 points·8 days ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

Disagree on that part. 95.1% and 98.9% on the same vial is normal.

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u/incretin_ivypharmacology80 points·9 days ago·edited

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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