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c/tirzepatide·submitted 26 days ago by u/dario_vermeulen

my resting HR went from 58 to 66 on titration and settled back

Questionbranch of 5 comments

tirzepatide. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does. I say this having got it wrong for 12…

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5 comments, started 25 days ago
u/yusuf_ramos13 points·25 days ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/alcohol_aversion9 points·25 days ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/marit_sandvik10 points·25 days ago

Three years on this site and the questions have not changed at all.

Disagree on that part. 99.0% and 98.9% on the same vial is normal.

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u/kofi_balogun5 points·25 days ago

This matches the trial data. SURMOUNT-1 was 93.7% body weight at 20 weeks.

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u/dario_vermeulenOP6 points·25 days ago

Week 73 on Mounjaro and 42kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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