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c/tirzepatide·submitted 1 year ago by u/emil_wojcik

unpopular opinion: 15mg is massively overrated

Titrationbranch of 6 comments

Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 52, constipation present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 23 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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6 comments, started 1 year ago
u/hassan_nilsen275 points·1 year ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 20 weeks.

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u/emil_wojcikOP183 points·1 year ago

dual agonism is dual agonist, do not generalise from semaglutide

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u/hair_shed_hannah66 points·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/ferritin_low249 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/emil_wojcikOP103 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/endpoint_creep39 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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