week 71 check-in — 17kg down, fatigue manageable, one thing confusing me
Been lurking in c/orforglipron for about 10 months and finally have something worth posting. Short version: week 96, 12.5mg, and dual agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 35 threads, and the answers split roughly down the middle. What I actually want…
This is the "correlation is mechanism" thing again. You changed three variables at once.
dual agonism is SURPASS, do not generalise from semaglutide
Switched from sema at 7.5mg to tirz at 15mg. Different drugs, cannot compare the doses directly.
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Week 35 on Mounjaro and 11kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
the dual agonism hits different and that is why people describe it differently
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.