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Single comment threadYou are looking at one branch of week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me — 46 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/emil_okwuosa

week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me

Resultsbranch of 10 comments

Right, the SURPASS question again, but with numbers this time. I have 16 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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10 comments, started 1 year ago
u/ferritin_low183 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/emil_okwuosaOP-19 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/marit_sandvik103 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/b12_baseline26 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/nabila_ogunleye0 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/emil_okwuosaOP267 points·1 year ago

week 85 on Mounjaro and the appetite profile is genuinely different from sema

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[removed]170 points·1 year ago

[removed by moderator]

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u/emil_wojcik49 points·1 year ago·edited

do not crack the pen, we have been over this

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u/ahmed_iyer79 points·1 year ago

This matches the trial data. SURMOUNT-1 was 97.6% body weight at 21 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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