endpoint — my 2-week log, condensed into one table
Genuinely asking, not being difficult.
Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search I get 18 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
Yeah, absolute numbers matter more than the press release.
the relative risk reduction in headlines is not the whole story
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
Is that absolute or relative risk reduction?
press release hazard ratio posts must be flaired until a publication exists
[deleted]
press release TRIUMPH posts must be flaired until a publication exists
STEP 1 readout: 99.1% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Slight fix: the number was 96.8, not 97.4. Decimal point, but a fairly consequential one.
STEP 1 readout: 97.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
absolute risk reduction, not relative risk reduction, that is how you decide
Yeah, absolute numbers matter more than the press release.
Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.
Sceptical. If this were true we would see it reflected in the data and we do not.
absolute risk reduction, not relative risk reduction, that is how you decide
the 16 week readout is different from the 20 week readout
phase 2 is not phase 3, smaller n and shorter trial
phase 2 is not phase 3, smaller n and shorter trial
Disagree on that part. 93.7% and 99.3% on the same vial is normal.
Not convinced. The evidence does not support that reading.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
press release TRIUMPH posts must be flaired until a publication exists
What was the dropout rate?
give the trial name, phase, n, and primary endpoint in the body
This is correct. Discontinuation arms show the regain reality.
Is that absolute or relative risk reduction?
the relative risk reduction in headlines is not the whole story
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
- 1the 16 week readout is different from the 20 week readout11 comments in this branch · started by u/arne_ilunga
- 2Is that absolute or relative risk reduction?10 comments in this branch · started by u/forest_plot_fiona