[Lab] 14th independent test on BCH, and the trend is the interesting part
I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe.
Material has been consistent. Communication has not. Shipping has varied by about 22 days on nominally the same lane, which matters more in summer than in February.
The independent number came back 99.0% against a claimed 98.0%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.
Batch number is in the comments. Ask if you want the method.
best — the order this archive was captured in
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
This is the "correlation is mechanism" thing again. You changed three variables at once.
event rates are more informative than hazard ratios alone
the discontinuation arms are the interesting part, not the SURPASS endpoints
STEP 1 readout: 98.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
STEP 1 readout: 93.7% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Is that absolute or relative risk reduction?
phase 2 is not phase 3, smaller n and shorter trial
STEP 1 readout: 97.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Strongly agree. Phase 2 is investigational, not conclusive.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
- 1the discontinuation arms are the interesting part, not the SURPASS endpoints8 comments in this branch · started by u/tomas_kimani