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c/trialwatch·submitted 1 months ago by u/cold_chromatogram31

[Meta] the endpoint rule is doing its job and people should stop complaining

Press Releasebranch of 8 comments

I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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8 comments, started 1 months ago
u/yusuf_ramos11 points·1 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/cold_chromatogram31OP16 points·1 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/paper_trail_paulavetting7 points·1 months ago·edited

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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[deleted]5 points·1 months ago

[deleted]

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u/ines_boateng2 points·1 months ago

Is that absolute or relative risk reduction?

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u/cold_chromatogram31OP7 points·1 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/cold_chromatogram31OP3 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/anders_karlsen5 points·1 months ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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