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c/trialwatch·submitted 2 months ago by u/whois_wanda

[Discussion] we are measuring SURPASS at the wrong time and calling it noise

Discussionbranch of 4 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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4 comments, started 2 months ago
u/nightowl_injector41 points·2 months ago

The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.

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u/whois_wandaOP18 points·2 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/whois_wandaOP31 points·2 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/kaia_cabrera40 points·2 months ago

Phase 2 TRIUMPH looked amazing.

Disagree on that part. 99.2% and 98.9% on the same vial is normal.

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