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c/trialwatch·posted 6 months ago by u/foam_head_fred

[Vendor] WXT order #6 — the Netherlands, 31 days, no drama, receipts inside

Stats Long Haul ×1 Cold Box ×2

Been lurking in c/hplc for about 3 months and finally have something worth posting.

Short version: week 38, 2.4mg, and hazard ratio is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 15 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 44.

1,286 up / 176 down88% upvoted29 commentsid 3lhwj329 Jan 2026

29 comments

5 in this archive, depth 2

best — the order this archive was captured in

u/niels_norgaard130 points·6 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/foam_head_fred63 points·6 months ago

off-label use data is different from approved-indication data

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u/first_hundred85 points·5 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/renal_outcomes_rnephro-curious59 points·6 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/yara_mensah35 points·6 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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