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Single comment threadYou are looking at one branch of reading FLOW threads from 2024 and half of it aged badly — 53 comments in the full submission. View in context.
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c/trialwatch·submitted 2 years ago by u/adaeze_weiss

reading FLOW threads from 2024 and half of it aged badly

Readoutbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 10 months without either producing anything. What would actually settle it is 3 people measuring the same thing…

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5 comments, started 2 years ago
u/naomi_ekstrom377 points·2 years ago

the discontinuation arms are the interesting part, not the endpoint endpoints

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u/hamza_zielinski184 points·2 years ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/eu_apotheke_a303 points·2 years ago

SELECT reported a SELECT hazard ratio but the absolute event rate is what changes clinical practice.

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u/milos_trevino85 points·2 years ago

Which trial and what was the primary endpoint?

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u/sanne_laurent109 points·2 years ago

off-label use data is different from approved-indication data

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