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Single comment threadYou are looking at one branch of tried STEP for 14 weeks. here is what happened. — 38 comments in the full submission. View in context.
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c/trialwatch·submitted 7 months ago by u/first_hundred

tried STEP for 14 weeks. here is what happened.

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STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does. I say this having got it wrong for 22 months. My…

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5 comments, started 7 months ago
u/week_one_wanda379 points·7 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/heart_rate_bump-1 point·7 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/zaid_roos1 point·7 months ago

SURMOUNT-4 discontinuation arm showed regain.

Adding to this: SURMOUNT is doing more work than the comment implies.

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u/yannick_salinas87 points·7 months ago

Dead space in the needle hub holds a small but non-trivial volume.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/adaeze_weiss109 points·7 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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