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c/trialwatch·posted 8 months ago by u/rohan_cardoso

hazard ratio: the version I wish someone had shown me in week 1

Paper

Quick one. Canada here.

endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 16 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

336 up / 374 down47% upvoted12 commentsid 4esfif23 Nov 2025

12 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/eu_apotheke_a9 points·8 months ago

press release SELECT posts must be flaired until a publication exists

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u/enzo_ferrari3 points·8 months ago

Disagree. What you are describing is consistent with hazard ratio, not with what you concluded.

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[removed]1 point·8 months ago

[removed by moderator]

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u/rohan_cardosoOP1 point·8 months ago

off-label use data is different from approved-indication data

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u/rohan_cardosoOP1 point·8 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/week_one_wanda1 point·8 months ago

What was the dropout rate?

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u/first_hundred2 points·8 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/nikhil_lindqvist2 points·8 months ago

dropout handling matters, especially on GI-heavy populations

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u/trialwatch_theoMOD6 points·8 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/rohan_cardosoOP4 points·8 months ago

Half-life is about 168 hours, so steady state lands around week 7–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/anders_vermeulen2 points·8 months ago

Phase 2 or phase 3?

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About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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