GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of [Meta] the STEP rule is doing its job and people should stop complaining — 31 comments in the full submission. View in context.
2.3k
c/trialwatch·submitted 5 months ago by u/anders_karlsen

[Meta] the STEP rule is doing its job and people should stop complaining

Readoutbranch of 9 comments

FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort FLOW out first, and almost nobody does. I say this having got it wrong for 14 months. My hs-CRP was the…

Read the full submission and all 31 comments →

This branch

9 comments, started 5 months ago
u/hazard_ratio_halMOD78 points·5 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

replysharereportpermalink
u/tomas_kimani60 points·5 months ago

phase 2 is not phase 3, smaller n and shorter trial

replysharereportpermalink
u/injection_site_iris42 points·5 months ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

replysharereportpermalink
u/ewan_tulloch50 points·5 months ago

the 23 week readout is different from the 8 week readout

replysharereportpermalink
u/trialwatch_theotrial nerd32 points·5 months ago

the 5 week readout is different from the 7 week readout

replysharereportpermalink
u/nhs_waitlist_nUK27 points·5 months ago

off-label use data is different from approved-indication data

replysharereportpermalink
u/sofia_wikstrom29 points·5 months ago

This is correct. Discontinuation arms show the regain reality.

replysharereportpermalink
u/ms_fragmenter22 points·5 months ago

give the trial name, phase, n, and primary endpoint in the body

replysharereportpermalink
u/sofia_ferreira16 points·5 months ago

the relative risk reduction in headlines is not the whole story

replysharereportpermalink

← back to the whole thread

About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →