small win: TRIUMPH stopped being a problem at week 45
Week 32 update. 43kg down from the start, reflux basically gone since about week 84.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
absolute risk reduction, not relative risk reduction, that is how you decide
give the trial name, phase, n, and primary endpoint in the body
number-needed-to-treat is the house dialect
number-needed-to-treat is the house dialect
Disagree on that part. 98.4% and 98.3% on the same vial is normal.
Small correction: the trial was 4 weeks, not 31. Does not change your point but people will quote it.
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That is net peptide content, not purity. Different number, different meaning.
dropout handling matters, especially on GI-heavy populations
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
the 4 week readout is different from the 6 week readout
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
This is correct. Discontinuation arms show the regain reality.
You have restated the marketing copy. What is the actual substance here.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
STEP 1 readout: 98.1% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
absolute risk reduction, not relative risk reduction, that is how you decide
Yeah, absolute numbers matter more than the press release.
This is correct. Discontinuation arms show the regain reality.
dropout handling matters, especially on GI-heavy populations
- 1number-needed-to-treat is the house dialect6 comments in this branch · started by u/britta_boateng
- 2Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on…5 comments in this branch · started by u/ahmed_iyer