u/bastian_ekstrom

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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Adding to this: dose escalation is doing more work than the comment implies.

Not to be pedantic but stability and lyophilised are being used interchangeably and they are not interchangeable in real life.

small molecule purity is different testing than peptides

Yeah, the network selection matters most.

glucagon-receptor contribution is mechanism for dual and triple agonism

How many weeks between the two measurements?

the logger trace is the data that matters, not the packaging promises

Rodent, human, or in vitro?

the half-life is gastric emptying, affects steady state timing

the half-life is half-life, affects steady state timing

receptor distribution matters, GLP-1 is not everywhere

The half-life is 12 hours, which means week 12 is genuinely still ramp-up. Week 26 is steady state.

Which paper are you quoting?

Strongly agree. Central appetite is real but people overstate it.

I am going to push back on this slightly.

the GIP side does different things than the GLP-1 side, that is the point

the half-life is half-life, affects steady state timing