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Comments — page 5 of 5

comment on reading Zepbound threads from 2024 and half of it aged badly in c/tirzepatide · 141 points · 1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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comment on am I the only one who found goal weight harder than the injections in c/maintenancephase · 69 points · 1 year ago

I am going to push back on this slightly.

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comment on phase 2 — my 12-week log, condensed into one table in c/retatrutide · 50 points · 1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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comment on formulary — 13 things I got wrong before I got it right in c/glp1canada · 7 points · 1 year ago

the Ireland answer is not the Ireland answer

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comment on why does nobody talk about dose escalation in c/retatrutide · 61 points · 1 year ago

That is net peptide content, not purity. Different number, different meaning.

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comment on why does nobody talk about pricing in c/glp1uk · 39 points · 1 year ago

^ this

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on someone explain glucagon to me like I have not read a paper in years in c/retatrutide · 107 points · 1 year ago

research use only, handling and analysis, not protocols

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comment on chromatogram: the version I wish someone had shown me in week 1 in c/hplc · 49 points · 1 year ago

co-elution is real and purity is usually not enough to resolve it

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comment on small win: goal weight stopped being a problem at week 20 in c/maintenancephase · 1 points · 1 year ago

lowest effective dose is long term, find it or stay higher

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comment on small win: GIP stopped being a problem at week 41 in c/tirzepatide · 40 points · 1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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comment on small win: GIP stopped being a problem at week 41 in c/tirzepatide · 18 points · 1 year ago

Week 6 on Mounjaro and 34kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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comment on small win: GIP stopped being a problem at week 41 in c/tirzepatide · 76 points · 1 year ago

the fatigue from tirz is different, not necessarily worse

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comment on stalled for 10 weeks at 5mg and I refuse to panic this time in c/hplc · 241 points · 1 year ago

The confident tone is doing a lot of work that the evidence is not.

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comment on stalled for 10 weeks at 5mg and I refuse to panic this time in c/hplc · 463 points · 1 year ago

Yeah, the chromatogram profile matters more than the headline number.

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comment on does phase 2 actually matter or is it forum lore at this point in c/retatrutide · 0 points · 1 year ago

This is correct. Triple agonism is genuinely different.

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comment on genuine question about amylin that I am slightly embarrassed to ask in c/cagrilintide · 10 points · 1 year ago

the mechanism is different, the side effect profile reflects it

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comment on the biopsy thing finally clicked for me and I want to write it down in c/survodutide · 0 points · 1 year ago

I am going to push back on this slightly.

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comment on dose escalation: what the trials say vs what this community says in c/retatrutide · 4 points · 1 year ago

Did you actually measure heart rate or is that a feeling?

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comment on [Discussion] the formulary advice in here is 21 years out of date in c/glp1canada · 123 points · 1 year ago

Small correction: the trial was 20 weeks, not 8. Does not change your point but people will quote it.

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comment on [Discussion] LC-MS is doing more work than we give it credit for in c/hplc · 43 points · 1 year ago

Did they post the raw trace or just the summary?

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