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Comments — page 3 of 5

comment on what changed for me between week 65 and week 19 in c/tirzepatide · 9 points · 4 months ago

Switched from sema at 2.5mg to tirz at 5mg. Different drugs, cannot compare the doses directly.

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comment on reading purity threads from 2024 and half of it aged badly in c/hplc · 25 points · 5 months ago

That is net peptide content, not purity. Different number, different meaning.

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comment on anyone else notice survodutide kicking in around week 9 in c/survodutide · 10 points · 5 months ago

glucagon injection is a different vector than GLP-1

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comment on private prescription vs tier 3 — genuinely asking which matters more in c/glp1uk · 11 points · 5 months ago

NHS tier 3 is MHRA, the waiting list is real

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comment on [Question] chromatogram — what am I missing here in c/hplc · 15 points · 5 months ago

chromatogram or it did not happen

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comment on [Results] 87 weeks, 46kg, and MHRA was the hard part in c/glp1uk · 54 points · 6 months ago

the tier 3 pathway is the only free route, it is slow

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comment on [Discussion] we are measuring tirzepatide at the wrong time and calling it noise in c/tirzepatide · 1 points · 6 months ago

Cosigning.

Yes, exactly this, and it is the bit that took me 2 weeks to accept.

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comment on [Question] Australia — has anyone got a straight answer on integration in c/hplc · 236 points · 6 months ago

Injection volume and flow rate? Those affect resolution.

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comment on [Vendor] WXT order #14 — Germany, 27 days, no drama, receipts inside in c/glp1uk · 5 points · 6 months ago

private prescription routes vary by region

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comment on help me understand MASH, I have read the wiki twice in c/survodutide · 17 points · 6 months ago

Phase 24 or 40?

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comment on switched from 1.0mg to 0.5mg and the injection-site soreness got better, not worse in c/maintenancephase · 6 points · 6 months ago

Small correction: the trial was 23 weeks, not 25.

Yes, exactly this, and it is the bit that took me 91 weeks to accept.

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comment on [Results] 46 weeks on 1.7mg, full numbers, ask me anything boring in c/cagrilintide · 25 points · 6 months ago

[removed by moderator]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on switched from 1.0mg to 0.5mg and the injection-site soreness got better, not worse in c/maintenancephase · 29 points · 6 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on anyone else notice 15mg kicking in around week 24 in c/tirzepatide · 220 points · 8 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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comment on survodutide vs glucagon — genuinely asking which matters more in c/survodutide · 20 points · 8 months ago

Yeah, glucagon co-agonism is genuinely different.

Yes, exactly this, and it is the bit that took me 77 weeks to accept.

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comment on [Question] purity — what am I missing here in c/hplc · 38 points · 8 months ago

Small correction: the trial was 23 weeks, not 27. Does not change your point but people will quote it.

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comment on small win: triple agonist stopped being a problem at week 61 in c/retatrutide · 50 points · 8 months ago

This is correct. Triple agonism is genuinely different.

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comment on retatrutide vs triple agonist — genuinely asking which matters more in c/retatrutide · 1 points · 8 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: TRIUMPH is doing more work than the comment implies.

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comment on Denmark: dual agonist, and what it actually costs here in c/survodutide · 26 points · 9 months ago

Yeah, glucagon co-agonism is genuinely different.

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