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c/cagrilintide·posted 7 months ago by u/andres_dahlberg

[Results] 46 weeks on 1.7mg, full numbers, ask me anything boring

Question Cold Box ×9 Clean Column ×1

I have had 21 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 18 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 97.9% against a claimed 94.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

1,247 up / 66 down95% upvoted63 commentsid 1ceuk41 Jan 2026

63 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/liv_dumitru92 points·6 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/emil_agyeman-8 points·6 months ago

Not to be pedantic but satiety and amylin are being used interchangeably and they are not interchangeable in real life.

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u/protein_first_pnutrition1 point·6 months ago

Are we talking amylin or GLP-1 here?

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u/hydration_hank1 point·6 months ago

long-acting amylin is co-agonism, different satiety profile

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u/ledger_modMOD61 points·6 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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[removed]45 points·6 months ago

[removed by moderator]

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u/crosspost_bot_no25 points·6 months ago

[removed by moderator]

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/zeynep_duarte16 points·6 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/emil_agyeman11 points·6 months ago

Are we talking amylin or GLP-1 here?

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u/hedda_aguirre73 points·6 months ago

Yeah, amylin is doing different work than GLP-1.

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u/hugo_pires59 points·6 months ago·edited

Strongly agree. REDEFINE is phase 8, not final.

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u/amara_halonen36 points·6 months ago

the mechanism is different, the side effect profile reflects it

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u/ms_fragmenter32 points·6 months ago·edited

the amylin agonist pool is small, community is amylin

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u/ferran_mensah25 points·6 months ago

the amylin agonist pool is small, community is amylin

Disagree on that part. 95.1% and 99.2% on the same vial is normal.

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u/rania_marchand14 points·6 months ago

amylin is not a GLP-1, posts conflating them get corrected

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u/nadia_fonseca15 points·6 months ago

Not convinced. The evidence does not support that reading.

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u/milos_vestergaard23 points·6 months ago

This is correct. The co-agonism is real.

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u/laila_dumitru14 points·6 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/emeka_beaulieu9 points·6 months ago

Rodent or human data?

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u/rina_sobczak4 points·6 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/andres_dahlbergOP10 points·6 months ago

Are we talking amylin or GLP-1 here?

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u/nz_unfunded15 points·6 months ago

This is correct. The co-agonism is real.

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u/lukas_vermeulen9 points·6 months ago

the mechanism is different, the side effect profile reflects it

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u/forest_plot_fionastats10 points·6 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/elin_lundgren3 points·6 months ago

Not to be pedantic but co-agonism and satiety are being used interchangeably and they are not interchangeable in real life.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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c/cagrilintide rules
  1. Amylin is not a GLP-1. Posts conflating them get corrected.
  2. CagriSema ratios in trials are fixed-dose. Do not extrapolate to self-mixing.
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