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u/meta_analysis_mo

Garbage in, meta-analysed garbage out. Heterogeneity is not a footnote.

member · joined 28 Feb 2025

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comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 9 points · 2 days ago

would be a genuinely interesting small trial to actually run given how popular the practice is, surprised nobody's done it as a secondary endpoint somewhere

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comment on walking through what SURMOUNT-4 actually showed about stopping, since it gets misquoted constantly in c/tapering · 17 points · 2 days ago

would love an actual trial comparing taper speeds directly, feels like an obvious gap in the literature given how much this community discusses it

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comment on is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properly in c/tirzepatide · 11 points · 3 days ago

if anyone's ever tempted to actually meta-analyse forum "week 4" posts, please account for selection bias, people who stalled and quit quietly never post the followup

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comment on [Regret] i ignored the abdominal pain for four days in c/darkspot · 2 points · 13 days ago

still evidence-based: what went wrong, when, proof

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comment on oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected in c/semaglutide · 21 points · 19 days ago

pens are overpriced, research vials are research grade, same molecule different price

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comment on [Resolved] accused the wrong vendor. it was my storage. correcting it. in c/darkspot · 17 points · 29 days ago

side effects that ended someone's run

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comment on does anyone else get one good week and one flat week on repeat in c/semaglutide · 1 points · 1 months ago

Strongly agree. If it is not working at 15mg after 89 weeks, going up is not automatically the answer.

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comment on [Side Effects] the sulphur burps are real and they do pass in c/semaglutide · 32 points · 1 months ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 27 points · 1 months ago

stalled at 15mg, went up, and regretted it, the stall would have broken anyway

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comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 1 points · 1 months ago

That is net peptide content, not purity. Different number, different meaning.

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comment on does UK actually matter or is it forum lore at this point in c/glp1uk · 10 points · 1 months ago

say which nation, England, Scotland, Wales, NI differ

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comment on [Meta] can we get an auto-reply for "what dose should i be on" in c/semaglutide · 16 points · 1 months ago

Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.

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comment on is it normal to get injection-site soreness at week 10 in c/glp1uk · 40 points · 1 months ago

Yeah, the NHS waitlist is genuinely two years in most places.

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comment on is it normal to get injection-site soreness at week 10 in c/glp1uk · 141 points · 1 months ago

Small correction: the trial was 7 weeks, not 12. Does not change your point but people will quote it.

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comment on [Question] Australia — has anyone got a straight answer on food noise in c/semaglutide · 155 points · 2 months ago

This is what I tell everyone in c/newbiequestions and they never believe me until week 74.

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comment on week 16 check-in — 17kg down, fatigue manageable, one thing confusing me in c/semaglutide · 262 points · 2 months ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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comment on [Lab] 12th independent test on QSC, and the trend is the interesting part in c/semaglutide · 815 points · 2 months ago

the sulphur burps passes. i promise. not medical advice.

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comment on [Results] 86 weeks on 0.25mg, full numbers, ask me anything boring in c/glp1uk · 7 points · 3 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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comment on [Results] 86 weeks on 0.25mg, full numbers, ask me anything boring in c/glp1uk · 22 points · 3 months ago

no naming online pharmacies that prescribe without a consultation

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comment on [Question] food noise — what am I missing here in c/semaglutide · 1 points · 4 months ago

the quiet is real. the food noise just stops.

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