u/renal_outcomes_r
FLOW changed how I think about eGFR slope. Renal endpoints deserve more airtime.
long-standing contributor · nephro-curious · joined 24 Mar 2025
Comments — page 2 of 5
comment on [Vendor] WXT order #24 — France, 29 days, no drama, receipts inside in c/glp1aus · 17 points · 3 months ago
the regulatory PBS is the blocker
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 2 points · 3 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 4 points · 3 months ago
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · -6 points · 3 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on am I the only one who found normal harder than the injections in c/newbiequestions · 30 points · 3 months ago
what is titration — it means going slow on the escalation
comment on endpoint — my 2-week log, condensed into one table in c/trialwatch · 30 points · 3 months ago
Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.
comment on normal: what the trials say vs what this community says in c/newbiequestions · -29 points · 3 months ago
Yeah, that is totally normal for week 3.
comment on week one is the most under-discussed thing in c/glp1science in c/newbiequestions · 32 points · 4 months ago
Small correction: the trial was 20 weeks, not 16. Does not change your point but people will quote it.
comment on [PSA] what is is not what most of this community thinks it is in c/newbiequestions · 206 points · 4 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Results] 22 weeks, 30kg, and EU was the hard part in c/glp1eu · 19 points · 5 months ago
Respectfully this is a sample of one presented as a finding.
comment on small win: SURMOUNT stopped being a problem at week 65 in c/trialwatch · 12 points · 5 months ago
the discontinuation arms are the interesting part, not the STEP endpoints
comment on [Vendor] WXT order #6 — the Netherlands, 31 days, no drama, receipts inside in c/trialwatch · 59 points · 6 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Vendor] QST order #4 — Spain, 7 days, no drama, receipts inside in c/newbiequestions · 6 points · 6 months ago
Week 6 checking in: nothing on the scale, no nausea, wondering if the pen is broken. No, it is just week 6.
comment on genuine question about hazard ratio that I am slightly embarrassed to ask in c/trialwatch · 12 points · 6 months ago
Respectfully this is a sample of one presented as a finding.
comment on the week one thing finally clicked for me and I want to write it down in c/newbiequestions · 22 points · 6 months ago
what is a COA — certificate of analysis, document from the lab
comment on is it normal to get injection-site soreness at week 65 in c/glp1eu · 34 points · 7 months ago
EMA and national agency claims need citation
comment on the normal thing finally clicked for me and I want to write it down in c/newbiequestions · 115 points · 9 months ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on FLOW vs TRIUMPH — genuinely asking which matters more in c/trialwatch · 46 points · 9 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on small win: hazard ratio stopped being a problem at week 51 in c/trialwatch · 94 points · 9 months ago
event rates are more informative than hazard ratios alone
comment on what is is the most under-discussed thing in c/glp1uk in c/newbiequestions · 1 points · 9 months ago
link the wiki instead of retyping, but politely