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c/trialwatch·posted 3 months ago by u/renal_outcomes_r

someone explain FLOW to me like I have not read a paper in years

Paper

Quick one. Canada here.

endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 24 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

151 up / 48 down76% upvoted17 commentsid 14hvoo24 Apr 2026

17 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/rina_sobczak11 points·3 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/emil_agyeman3 points·3 months ago·edited

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/eu_apotheke_a1 point·3 months ago

the relative risk reduction in headlines is not the whole story

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u/renal_outcomes_rOPnephro-curious-6 points·3 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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[removed]1 point·3 months ago

[removed by moderator]

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u/ines_boateng8 points·3 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/heart_rate_bump5 points·3 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/renal_outcomes_rOPnephro-curious4 points·3 months ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/hsa_math2 points·3 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/adaeze_weiss1 point·3 months ago

event rates are more informative than hazard ratios alone

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u/forest_plot_fionastats1 point·3 months ago

This is correct. Discontinuation arms show the regain reality.

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u/renal_outcomes_rOPnephro-curious2 points·3 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/hugo_norgaard7 points·3 months ago

SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.

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u/alcohol_aversion5 points·3 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/hugo_norgaard1 point·3 months ago

off-label use data is different from approved-indication data

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u/marit_laurent2 points·3 months ago

press release SELECT posts must be flaired until a publication exists

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u/nightowl_injector1 point·3 months ago

the discontinuation arms are the interesting part, not the FLOW endpoints

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