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Single comment threadYou are looking at one branch of someone explain FLOW to me like I have not read a paper in years — 17 comments in the full submission. View in context.
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c/trialwatch·submitted 3 months ago by u/renal_outcomes_r

someone explain FLOW to me like I have not read a paper in years

Paperbranch of 7 comments

Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 24 weeks and cost roughly what I expected. The admin was worse than the…

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7 comments, started 3 months ago
u/ines_boateng8 points·3 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/heart_rate_bump5 points·3 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/renal_outcomes_rOPnephro-curious4 points·3 months ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/hsa_math2 points·3 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/adaeze_weiss1 point·3 months ago

event rates are more informative than hazard ratios alone

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u/forest_plot_fionastats1 point·3 months ago

This is correct. Discontinuation arms show the regain reality.

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u/renal_outcomes_rOPnephro-curious2 points·3 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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