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reading SURPASS threads from 2024 and half of it aged badly
Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I…
u/rt_shift_reggie
Retention time shifted 0.4 min and nobody wants to talk about it.
member · joined 19 Mar 2025
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Overview — page 3 of 5
comment on [Results] 87 weeks, 46kg, and MHRA was the hard part in c/glp1uk · 21 points · 6 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on what changed for me between week 20 and week 63 in c/compounding · 80 points · 6 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Meta] proposal — a flair for co-agonism posts in c/cagrilintide · 77 points · 6 months ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on stalled for 5 weeks at 0.25mg and I refuse to panic this time in c/newbiequestions · 69 points · 6 months ago
Yeah, that is totally normal for week 5.
comment on [Discussion] we are measuring EU at the wrong time and calling it noise in c/glp1eu · 21 points · 7 months ago
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
comment on my hs-CRP moved and I cannot work out whether FLOW is why in c/trialwatch · 25 points · 7 months ago
press release hazard ratio posts must be flaired until a publication exists
comment on help me understand first time, I have read the wiki twice in c/newbiequestions · 106 points · 7 months ago
Crossposting this to c/meta because the people who need it are not reading this community.
comment on three years of week one threads, summarised so you do not have to read them in c/newbiequestions · 48 points · 7 months ago
Not convinced. The evidence does not support that reading.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · 28 points · 8 months ago
Half-life is about 168 hours, so steady state lands around week 17–5.
Yes, exactly this, and it is the bit that took me 45 weeks to accept.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · -14 points · 8 months ago
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · 55 points · 8 months ago
nope. mine was the opposite.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · 20 points · 8 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Question] how do you actually verify prescription in c/glp1eu · 94 points · 8 months ago
Sceptical. If this were true we would see it reflected in the data and we do not.
comment on [Results] 96 weeks on 0.25mg, full numbers, ask me anything boring in c/newbiequestions · 20 points · 8 months ago
link the wiki instead of retyping, but politely
663
pharmacy vs prescription — genuinely asking which matters more
I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
comment on what is: what the trials say vs what this community says in c/newbiequestions · 23 points · 11 months ago
link the wiki instead of retyping, but politely
Yes, exactly this, and it is the bit that took me 74 weeks to accept.
comment on week 21 check-in — 27kg down, sulphur burps manageable, one thing confusing me in c/glp1eu · 47 points · 12 months ago
Strongly agree. Pricing is local.
comment on does MHRA actually matter or is it forum lore at this point in c/glp1uk · -37 points · 1 year ago
Respectfully this is a sample of one presented as a finding.
comment on [Question] Australia — has anyone got a straight answer on what is in c/newbiequestions · 60 points · 1 year ago
You have restated the marketing copy. What is the actual substance here.