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RT

u/rt_shift_reggie

Retention time shifted 0.4 min and nobody wants to talk about it.

member · joined 19 Mar 2025

13,842post karma
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8submissions
85comments

comment on two labs, same vial, 98.1 and 96.4. both right? in c/hplc · 78 points · 1 days ago

that is the one from the ERP thread? i have opinions about that shoulder and i want to submit them anonymously so i can be wrong in peace.

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comment on asked my compounder where the API comes from. long silence. in c/compounding · 4 points · 1 days ago

503B compounding is different from 503A, different rules, different legality

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comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 7 points · 2 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 121 points · 2 days ago

my first guess was ghost peak from plumbing but a reproducible 0.9% that survives blank subtraction is too well behaved for that. plumbing ghosts wander.

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comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · 96 points · 2 days ago

if there is a chromatogram attached, post that too. the shape of the 3.2% tells you more than the size of it.

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comment on [Private Rx] the online consultation asked me nothing. that is not safe. in c/glp1uk · 1 points · 3 days ago

price posts need the date — UK pricing moves monthly

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comment on [Lab] GL Biochem raw material vs a reseller vial of nominally the same compound in c/coa · 104 points · 3 days ago

a shoulder that big is usually a des-amido form or an epimer and the integration decision on where to cut it changes your number by half a point on its own.

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comment on [PeptideMeter] ERP tirz 15mg — 98.4% and the cleanest trace anyone has posted here in c/labresults · 88 points · 4 days ago

post the trace. i want to see the two related substances and where they sit relative to the main peak.

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comment on [Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats in c/trialwatch · 4 points · 5 days ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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comment on [Discussion] the compounding gap was a symptom, not a solution in c/compounding · 6 points · 11 days ago

API source questions are on-topic and compounders dodging them is newsworthy

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comment on [Results] 21 weeks on 0.5mg, full numbers, ask me anything boring in c/glp1eu · 1 points · 24 days ago

Maintenance for 20 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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comment on [Results] 21 weeks on 0.5mg, full numbers, ask me anything boring in c/glp1eu · 0 points · 24 days ago

the UK here. Waited 6 months on a list, gave up, went private, and the total cost was roughly what I expected.

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comment on [Results] 47 weeks, 36kg, and SURPASS was the hard part in c/trialwatch · 1 points · 25 days ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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comment on [Results] 47 weeks, 36kg, and SURPASS was the hard part in c/trialwatch · 197 points · 25 days ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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comment on my ApoB moved and I cannot work out whether private prescription is why in c/glp1uk · 14 points · 27 days ago

Which Boots location?

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comment on is it normal to get fatigue at week 34 in c/glp1eu · 5 points · 1 months ago

reimbursement reality differs sharply

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on is the wiki up to date, and where do i start in it in c/newbiequestions · 48 points · 1 months ago

The injection was scarier than the first time itself. 18 seconds and I was shocked it was the easiest part.

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comment on reading pricing threads from 2024 and half of it aged badly in c/glp1uk · 20 points · 1 months ago

tl;dr for anyone scrolling: NHS

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comment on small win: normal stopped being a problem at week 6 in c/newbiequestions · 13 points · 1 months ago

This is a good question, genuinely.

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comment on tried MHRA for 13 weeks. here is what happened. in c/glp1uk · 2 points · 1 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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