[Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats
Week 22 update. 43kg down from the start, reflux basically gone since about week 62.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
event rates are more informative than hazard ratios alone
STEP 1 readout: 99.0% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
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event rates are more informative than hazard ratios alone
Disagree but this is the good kind of wrong — it is specific enough to be checked.
This is correct. Discontinuation arms show the regain reality.
phase 2 is not phase 3, smaller n and shorter trial
the discontinuation arms are the interesting part, not the endpoint endpoints
the relative risk reduction in headlines is not the whole story
event rates are more informative than hazard ratios alone
Retitled to remove editorialising. Put the evidence in the body.
Crossposting this to c/glp1muscle because the people who need it are not reading this community.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
What was the dropout rate?
SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.
Strongly agree. Phase 2 is investigational, not conclusive.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
press release hazard ratio posts must be flaired until a publication exists
The confident tone is doing a lot of work that the evidence is not.
the 23 week readout is different from the 20 week readout
- 1event rates are more informative than hazard ratios alone6 comments in this branch · started by u/valeria_karlsen
- 2Disagree but this is the good kind of wrong — it is specific enough to be…6 comments in this branch · started by u/camila_vasquez