[Results] 47 weeks, 36kg, and SURPASS was the hard part
Trying to settle this properly because the thread from last year went in circles.
The claim: STEP matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 20 months without either producing anything.
What would actually settle it is 13 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.
Not convinced. The evidence does not support that reading.
Sceptical. If this were true we would see it reflected in the data and we do not.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
What was the dropout rate?
Disagree. What you are describing is consistent with FLOW, not with what you concluded.
phase 2 is not phase 3, smaller n and shorter trial
Strongly agree. Phase 2 is investigational, not conclusive.
Yeah, absolute numbers matter more than the press release.
the 6 week readout is different from the 7 week readout
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
off-label use data is different from approved-indication data
press release hazard ratio posts must be flaired until a publication exists
the discontinuation arms are the interesting part, not the SURMOUNT endpoints
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
off-label use data is different from approved-indication data
off-label use data is different from approved-indication data
Yes, exactly this, and it is the bit that took me 72 weeks to accept.
Strongly agree. Phase 2 is investigational, not conclusive.
dropout handling matters, especially on GI-heavy populations
This is correct. Discontinuation arms show the regain reality.
give the trial name, phase, n, and primary endpoint in the body
Small correction: the trial was 2 weeks, not 16. Does not change your point but people will quote it.
Yeah, absolute numbers matter more than the press release.
the relative risk reduction in headlines is not the whole story
This is correct. Discontinuation arms show the regain reality.
- 1the 6 week readout is different from the 7 week readout15 comments in this branch · started by u/zaid_roos
- 2Half-life is about 168 hours, so steady state lands around week 20–5.…9 comments in this branch · started by u/rt_shift_reggie