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c/newbiequestions·posted 8 months ago by u/ruben_cabrera

[Results] 96 weeks on 0.25mg, full numbers, ask me anything boring

Question Long Haul ×2

Right, the week one question again, but with numbers this time.

I have 21 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 92, not week 46. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

730 up / 176 down81% upvoted27 commentsid 1r7p762 Nov 2025

27 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/asks_dumb_questions69 points·8 months ago

Mechanistically the bit that matters is normal. It explains most of the early profile and a decent chunk of the outcome.

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u/hugo_norgaard34 points·8 months ago

Respectfully this is a sample of one presented as a finding.

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u/gentle_correctionMOD46 points·8 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/plain_titration13 points·8 months ago

Half-life is about 168 hours, so steady state lands around week 3–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/ruben_cabreraOP-24 points·8 months ago

This is a good question, genuinely.

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u/rekha_teixeira1 point·8 months ago

Strongly agree. No question is dumb here.

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u/arne_restrepo1 point·8 months ago

is this normal week 18 — yes, probably

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u/adaeze_cabrera1 point·8 months ago

week two nothing happening — yes, that is normal

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u/sanne_laurent10 points·8 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/ruben_cabreraOP5 points·8 months ago

The beginner question took me three weeks to understand. Wiki explained it eventually.

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u/ruben_cabreraOP26 points·8 months ago

The first time question took me three weeks to understand. Wiki explained it eventually.

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u/rt_shift_reggie20 points·8 months ago·edited

link the wiki instead of retyping, but politely

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u/elise_grimaldi28 points·8 months ago

Week 9 checking in: nothing on the scale, no nausea, wondering if the pen is broken. No, it is just week 9.

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u/piotr_grimaldi9 points·8 months ago·edited

Pens or research vials?

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u/hugo_norgaard7 points·8 months ago

Yeah, that is totally normal for week 15.

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u/micro_bump_mick5 points·8 months ago

what is a COA — certificate of analysis, document from the lab

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u/dario_bakken20 points·8 months ago·edited

Yeah, that is totally normal for week 19.

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