u/sig_figs_sam
c/hplc mod. Analytical chemist by trade. Round your numbers responsibly.
moderator · mod · analytical · joined 14 Dec 2023
Overview — page 3 of 5
comment on [Question] method development — what am I missing here in c/hplc · 3 points · 3 months ago
Ran the same vial on two columns, different purity, both right, different separation. Method matters more than equipment.
comment on [Discussion] the incretin advice in here is 14 years out of date in c/glp1science · 7 points · 3 months ago
source?
Disagree on that part. 97.4% and 98.3% on the same vial is normal.
comment on integration vs purity — genuinely asking which matters more in c/hplc · 7 points · 3 months ago
Slight fix: the number was 98.7, not 98.9. Decimal point, but a fairly consequential one.
comment on what would you tell week-1 you about LC-MS in c/hplc · 154 points · 3 months ago
Small correction: the trial was 16 weeks, not 30. Does not change your point but people will quote it.
comment on [Meta] proposal — a flair for gastric emptying posts in c/glp1science · 3 points · 3 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on switched from 1.0mg to 0.5mg and the sulphur burps got better, not worse in c/hplc · 187 points · 3 months ago
A shoulder on the main peak that 10 analysts integrated 38 different ways. Same trace, 96.8 spread.
comment on [Results] 42 weeks, 21kg, and purity was the hard part in c/coa · 363 points · 3 months ago
axis labels included, always
comment on COA: what the trials say vs what this community says in c/coa · 1 points · 4 months ago
area% is not mass%, and here is exactly why it matters
Yes, exactly this, and it is the bit that took me 10 weeks to accept.
comment on COA: what the trials say vs what this community says in c/coa · 161 points · 4 months ago
purity and net content are two different numbers, same vial
comment on three years of integration threads, summarised so you do not have to read them in c/hplc · 126 points · 4 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on water content — 5 things I got wrong before I got it right in c/coa · 220 points · 4 months ago
PDF metadata is checkable in fifteen seconds
comment on France: chromatogram, and what it actually costs here in c/hplc · 40 points · 4 months ago
Detection wavelength? LC-MS and that changes at different wavelengths.
comment on someone explain HPLC to me like I have not read a paper in years in c/hplc · 34 points · 4 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on someone explain Janoshik to me like I have not read a paper in years in c/vendorvetting · 15 points · 5 months ago
the Janoshik result being close to the claim is the signal, not the absolute number
comment on am I the only one who found area percent harder than the injections in c/coa · 402 points · 5 months ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on [Results] 17 weeks, 10kg, and LC-MS was the hard part in c/hplc · 3 points · 5 months ago
Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.
comment on [Discussion] order records is doing more work than we give it credit for in c/vendorvetting · 48 points · 5 months ago
the PeptideMeter result being close to the claim is the signal, not the absolute number
comment on nobody warned me about nausea and I would have liked the warning in c/coa · 81 points · 5 months ago
the batch number or it did not happen
comment on [Question] chromatogram — what am I missing here in c/hplc · 164 points · 5 months ago
Tracking number removed. It identifies both ends of a shipment.
comment on tried HPLC for 6 weeks. here is what happened. in c/hplc · 24 points · 6 months ago
the detector wavelength matters more than people think