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c/coa·posted 4 months ago by u/anya_moreau

water content — 5 things I got wrong before I got it right

COA Well Actually ×6 Long Haul ×1 Clean Column ×1

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 35 reads it before doing the same thing.

3,306 up / 95 down97% upvoted62 commentsid ylcwbl15 Mar 2026

62 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/fatima_wojcik368 points·4 months ago·edited

Four months on the site and I was confusing area% and mass% in every post I made. One explainer thread and it clicked.

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u/karma_irrelevant129 points·4 months ago

the counterion is part of the mass you paid for

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u/mikkel_correia100 points·4 months ago

redact your own name, not the vendor's batch details

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u/sig_figs_sammod · analytical220 points·4 months ago

PDF metadata is checkable in fifteen seconds

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u/anya_moreauOP126 points·4 months ago

Small correction: the trial was 20 weeks, not 7. Does not change your point but people will quote it.

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u/stablecoin_steve86 points·4 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/soren_zamora41 points·4 months ago

PDF metadata is checkable in fifteen seconds

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u/yannick_haddad22 points·4 months ago

the related substances line is where the story is

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u/andres_restrepo9 points·4 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/yara_antonsen51 points·4 months ago·edited

the batch number or it did not happen

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u/vito_chowdhury33 points·4 months ago

redact your own name, not the vendor's batch details

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u/anya_moreauOP14 points·4 months ago

area% is not mass%, and here is exactly why it matters

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u/emil_agyeman17 points·4 months ago

Water content on the document? That affects your concentration math.

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u/emeka_chowdhury100 points·4 months ago

purity and net content are two different numbers, same vial

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u/first_hundredMOD104 points·4 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/katrin_girard323 points·4 months ago

Did they give you the chromatogram or just the summary line?

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u/halima_boateng151 points·4 months ago·edited

area% is not mass%, and here is exactly why it matters

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u/ghrp_history123 points·4 months ago·edited

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/hugo_bergstrom0 points·4 months ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/cesar_ivaturi65 points·4 months ago

Four months on the site and I was confusing area% and mass% in every post I made. One explainer thread and it clicked.

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u/anya_moreauOP46 points·4 months ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/cesar_ivaturi44 points·4 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/zaid_balogun30 points·4 months ago

the counterion is part of the mass you paid for

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u/freya_baptista86 points·4 months ago
controversial sort brought me here and it was worth it
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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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