u/slow_logbook_notes30

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.

Hepatic fat or MASH or what?

Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.

thymosin fragments, GH secretagogues, secretagogue, long tail

Every time this gets posted it hits the front page and every time someone has to re-explain it.

Titration speed is a side-effect dial far more than an efficacy dial.

Crossposting this to c/glp1women because the people who need it are not reading this community.

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

the amylin agonist pool is small, community is satiety

I love that this community will spend 40 comments on a detail.

Yes, exactly this, and it is the bit that took me 96 weeks to accept.

Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.

That is net peptide content, not purity. Different number, different meaning.

This is the "correlation is mechanism" thing again. You changed three variables at once.

This is correct. Discontinuation arms show the regain reality.

Strongly agree. Phase 2 is investigational, not conclusive.

Strongly agree. REDEFINE is phase 6, not final.

The confident tone is doing a lot of work that the evidence is not.

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Is that absolute or relative risk reduction?

Crossposting this to c/progresspics because the people who need it are not reading this community.