three years of REDEFINE threads, summarised so you do not have to read them
Been lurking in c/orforglipron for about 16 months and finally have something worth posting.
Short version: week 70, 12.5mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 70.
best — the order this archive was captured in
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
Half-life is about 168 hours, so steady state lands around week 21–5. Practical consequence: what you feel in week 1 is not what that dose does.
Titration speed is a side-effect dial far more than an efficacy dial.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
the amylin agonist pool is small, community is REDEFINE
Every time this gets posted it hits the front page and every time someone has to re-explain it.
REDEFINE phase 18 readouts are interesting but 18 person CagriSema is different from 18 trial CagriSema.
This is correct. The co-agonism is real.
long-acting amylin is co-agonism, different satiety profile
research use only, no human protocols in posts
Yeah, amylin is doing different work than GLP-1.
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
Yeah, amylin is doing different work than GLP-1.
CagriSema is a fixed combo in trials, not user-mixed
REDEFINE phase 9 readouts are interesting but 9 person amylin is different from 9 trial amylin.
CagriSema is a fixed combo in trials, not user-mixed
the co-agonism question is real and interesting
Respectfully this is a sample of one presented as a finding.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Rodent or human data?
amylin is not a GLP-1, posts conflating them get corrected
amylin is not a GLP-1, posts conflating them get corrected
Adding to this: REDEFINE is doing more work than the comment implies.
- 1Every time this gets posted it hits the front page and every time someone…8 comments in this branch · started by u/slow_logbook_notes30
- 2The evidence standard in c/vendorvetting gets called too strict about once a…5 comments in this branch · started by u/ice_pack_audit