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c/cagrilintide·submitted 1 year ago by u/hedda_aguirre

three years of REDEFINE threads, summarised so you do not have to read them

Trial Databranch of 8 comments

Been lurking in c/orforglipron for about 16 months and finally have something worth posting. Short version: week 70, 12.5mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle. What I actually want to know…

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8 comments, started 1 year ago
u/slow_logbook_notes3039 points·1 year ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/hedda_aguirreOP56 points·1 year ago

REDEFINE phase 18 readouts are interesting but 18 person CagriSema is different from 18 trial CagriSema.

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u/bpc_scepticresearch peptides19 points·1 year ago

This is correct. The co-agonism is real.

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u/hana_pereira8 points·1 year ago

This is correct. The co-agonism is real.

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u/signe_grimaldi8 points·1 year ago

long-acting amylin is co-agonism, different satiety profile

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u/viktor_erdogan2 points·1 year ago

research use only, no human protocols in posts

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u/hedda_aguirreOP-27 points·1 year ago

Yeah, amylin is doing different work than GLP-1.

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[deleted]1 point·1 year ago

[deleted]

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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