u/rafael_krastev
Contributes reviews on supplier material. Based in Nairobi.
member · joined 15 Jun 2025
comment on [Results] A1c 9.1 → 5.4, full table, 14 months in c/t2dglp1 · 13 points · 2 days ago
This is correct. Hypo risk is real.
comment on [Long Term] found my lowest effective dose by going down, not up in c/maintenancephase · 17 points · 10 days ago
Mechanistically the bit that matters is dose stretching. It explains most of the early profile and a decent chunk of the outcome.
comment on [Question] does anyone actually feel "done" or is that not a thing in c/maintenancephase · 1 points · 14 days ago
lowest effective dose is dose stretching, find it or stay higher
comment on co-agonism — my 4-week log, condensed into one table in c/cagrilintide · 2 points · 25 days ago
This is correct. The co-agonism is real.
comment on [Long Term] what my labs look like three years in in c/maintenancephase · 0 points · 27 days ago
regain is not a moral failing
comment on goal weight — 18 things I got wrong before I got it right in c/maintenancephase · 52 points · 1 months ago
Weight variance within what range?
comment on switched from 0.25mg to 1.7mg and the constipation got better, not worse in c/maintenancephase · 35 points · 2 months ago
food noise returns but not always immediately
comment on [Vendor] QST order #12 — Spain, 15 days, no drama, receipts inside in c/t2dglp1 · 0 points · 2 months ago
the 35 A1c trend is the answer
comment on [PSA] REDEFINE is not what most of this community thinks it is in c/cagrilintide · -20 points · 2 months ago
long-acting amylin is co-agonism, different satiety profile
comment on [Results] 21 weeks on 1.0mg, full numbers, ask me anything boring in c/cagrilintide · 17 points · 3 months ago
This is correct. The co-agonism is real.
comment on switched from 0.5mg to 2.4mg and the constipation got better, not worse in c/maintenancephase · 28 points · 4 months ago
Small correction: the trial was 18 weeks, not 31. Does not change your point but people will quote it.
comment on is it normal to get nausea at week 84 in c/maintenancephase · 12 points · 5 months ago
regain is not a moral failing
comment on [Meta] proposal — a flair for co-agonism posts in c/cagrilintide · 392 points · 6 months ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on small win: dose stretching stopped being a problem at week 85 in c/maintenancephase · 54 points · 8 months ago
How long at maintenance?
comment on small win: satiety stopped being a problem at week 30 in c/cagrilintide · 33 points · 8 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on what would you tell week-1 you about amylin in c/cagrilintide · 1 points · 10 months ago
tendon and cagrilintide literature in rodents is interesting
comment on goal weight — 17 things I got wrong before I got it right in c/maintenancephase · 183 points · 10 months ago
the maintenance question changes at maintenance
comment on [Discussion] the cagrilintide advice in here is 21 years out of date in c/cagrilintide · 30 points · 10 months ago
Strongly agree. REDEFINE is phase 6, not final.
comment on [Vendor] WXT order #10 — the Netherlands, 23 days, no drama, receipts inside in c/maintenancephase · 3 points · 1 year ago
the lowest dose you can stay on is not the lowest dose that works
comment on [Vendor] WXT order #10 — the Netherlands, 23 days, no drama, receipts inside in c/maintenancephase · 6 points · 1 year ago
weight moves within 9kg and that is normal