[Results] 21 weeks on 1.0mg, full numbers, ask me anything boring
Genuinely asking, not being difficult.
Everyone in c/hplc repeats that satiety is important. I believe it, but I have never seen anyone show why, and when I search I get 14 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
This is correct. The co-agonism is real.
Small correction: the trial was 12 weeks, not 27. Does not change your point but people will quote it.
not approved anywhere, keep posts descriptive, not instructional
Are we talking amylin or GLP-1 here?
the amylin agonist pool is small, community is satiety
Are we talking amylin or GLP-1 here?
CagriSema is a fixed combo in trials, not user-mixed
the co-agonism question is real and interesting
tendon and CagriSema literature in rodents is interesting
REDEFINE readouts are phase 6 data
not approved anywhere, keep posts descriptive, not instructional
the co-agonism question is real and interesting
Crossposting this to c/vendorvetting because the people who need it are not reading this community.
Disagree. What you are describing is consistent with CagriSema, not with what you concluded.
long-acting amylin is co-agonism, different satiety profile
not approved anywhere, keep posts descriptive, not instructional
the mechanism is different, the side effect profile reflects it
Not to be pedantic but CagriSema and amylin are being used interchangeably and they are not interchangeable in real life.
Are we talking amylin or GLP-1 here?
Mechanistically the bit that matters is REDEFINE. It explains most of the early profile and a decent chunk of the outcome.
tendon and CagriSema literature in rodents is interesting
Yeah, amylin is doing different work than GLP-1.
Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.
This is correct. The co-agonism is real.
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does cagrilintide.
This is correct. The co-agonism is real.
REDEFINE which arm?
not approved anywhere, keep posts descriptive, not instructional
- 1This is correct. The co-agonism is real.7 comments in this branch · started by u/ms_fragmenter
- 2Crossposting this to c/vendorvetting because the people who need it are not…7 comments in this branch · started by u/elin_lundgren