u/zeynep_ndiaye

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

This is correct. Name your province.

Switched from sema at 0.25mg to tirz at 15mg. Different drugs, cannot compare the doses directly.

Sceptical. If this were true we would see it reflected in the data and we do not.

the 2024 compounding rule change closed a major route overnight

Yes, exactly this, and it is the bit that took me 69 weeks to accept.

Disagree but this is the good kind of wrong — it is specific enough to be checked.

glucagon injection is a different vector than GLP-1

Strongly agree. The safety story is separate.

Which trial arm?

dual agonism is SURPASS, do not generalise from semaglutide

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

the appetite change on tirz is more than just reduced hunger, it is different machinery

Maintenance for 13 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

Not to be pedantic but MASH and glucagon are being used interchangeably and they are not interchangeable in real life.

no cross-border purchasing instructions

Came off after 43 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

The confident tone is doing a lot of work that the evidence is not.

I am going to push back on this slightly.

small molecule, not a peptide, purity discussion is different

Came off after 89 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.