[Question] Mounjaro — what am I missing here
Confession thread, sort of.
I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 94 reads it before doing the same thing.
best — the order this archive was captured in
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.
Tried both.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the dual agonism hits different and that is why people describe it differently
Disagree. What you are describing is consistent with 15mg, not with what you concluded.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Water content matters more than people think.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Removed a chain here. The rule is one line long and it is not negotiable.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Is that on Mounjaro pens or research tirzepatide?
the appetite change on tirz is more than just reduced hunger, it is different machinery
Is that on Mounjaro pens or research tirzepatide?
the GIP side does different things than the GLP-1 side, that is the point
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.
dual agonism is SURPASS, do not generalise from semaglutide
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
stalled on sema, tried tirz, and the curves were actually different shapes
Respectfully this is a sample of one presented as a finding.
- 1this deserves more than 6 upvotes9 comments in this branch · started by u/britt_okwuosa
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