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c/tirzepatide·submitted 1 year ago by u/ferritin_low

[Question] Mounjaro — what am I missing here

Questionbranch of 7 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I did…

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7 comments, started 1 year ago
u/rania_marchand430 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/britt_okwuosa351 points·1 year ago

Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.

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u/gentle_correctionnice about it160 points·1 year ago·edited

Tried both.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/elin_varga78 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/nabila_ogunleye-16 points·1 year ago

Disagree. What you are describing is consistent with 15mg, not with what you concluded.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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