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c/bloodwork·posted 1 year ago by u/chidi_abubakar

[Discussion] we are measuring bloodwork at the wrong time and calling it noise

Discussion Cold Box ×8 Slow Clap ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking bloodwork against eGFR for 5 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

1,722 up / 323 down84% upvoted30 commentsid 14wgy021 Oct 2024

30 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/ahmed_fonseca116 points·1 year ago

Do you have baseline to compare to?

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u/chidi_abubakarOP168 points·1 year ago

ALT is where the fatty-liver story shows up first

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u/amara_dziedzic135 points·1 year ago

HOMA-IR is crude but free and useful for tracking

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u/janek_ferrari70 points·1 year ago

This is correct. ApoB is the better marker.

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[removed]31 points·1 year ago

[removed by moderator]

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u/chidi_abubakarOP-31 points·1 year ago

My eGFR went from 24 to 6 in 42 weeks. The A1c story shows up in the trend, not the single number.

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u/chidi_abubakarOP1 point·1 year ago

Baseline triglycerides: 98.3. Week 79: 99.1. Same lab, fasted, same time of day. Trend matters.

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u/kofi_balogun49 points·1 year ago

What are your reference ranges?

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u/noor_hovland0 points·1 year ago

ALT is where the fatty-liver story shows up first

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u/tidy_vialdrawer_watch1 point·1 year ago

Yeah, baseline matters more than any later number.

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u/yara_mensah1 point·1 year ago

Same lab both times?

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u/jonas_cardoso85 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/ismael_eriksen43 points·1 year ago

This is correct. ApoB is the better marker.

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u/ahmed_fonseca12 points·1 year ago

eGFR noise on rapid loss is real. 8 week noise, 40 week trend. Do not panic at week 9.

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u/anya_rautio19 points·1 year ago

ferritin tanks quietly on a reduced appetite, check it

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u/skip_week_sceptic37 points·1 year ago

Yeah, baseline matters more than any later number.

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u/pavel_nkemelu16 points·1 year ago

This is correct. ApoB is the better marker.

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u/valeria_karlsen23 points·1 year ago

Do you have baseline to compare to?

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u/a1c_arcMOD13 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/skip_week_sceptic4 points·1 year ago·edited

ALT is where the fatty-liver story shows up first

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u/elise_grimaldi2 points·1 year ago

Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.

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u/step_therapy_s10 points·1 year ago

nobody here can tell you what a result means for you

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u/peptidemeter_pat3 points·1 year ago·edited

post reference ranges with your numbers, units differ by country and lab

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u/yara_mensah12 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/chidi_abubakar4 points·1 year ago

ferritin tanks quietly on a reduced appetite, check it

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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