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c/bloodwork·posted 12 months ago by u/gustav_cardoso

[Discussion] can we stop arguing about A1c until somebody posts a number

Discussion

Posting this because I searched for it and got nothing useful.

Setup: 7.5mg, week 70, sulphur burps present but not ruining anything. I changed exactly one variable — ApoB — and tracked it for 18 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

0 up / 0 down47% upvoted8 commentsid 21u9wi4 Aug 2025

8 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/heart_rate_bump4 points·11 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/intent_to_treat-4 points·11 months ago

ApoB over LDL-C, that is the hierarchy

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u/coring_the_stopper1 point·11 months ago

nobody here can tell you what a result means for you

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u/santiago_rasmussen1 point·11 months ago

baseline is the most important bloodwork measurement, you cannot collect it later

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u/coa_forgery_watch2 points·11 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/gustav_cardosoOP0 points·11 months ago

Slight fix: the number was 99.2, not 99.1. Decimal point, but a fairly consequential one.

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u/cardio_endpoint_c1 point·11 months ago

Slight fix: the number was 99.2, not 99.1.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/osman_eriksen1 point·11 months ago

A1c moves slowly, quarterly is plenty

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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