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c/cagrilintide·posted 4 months ago by u/ferritin_low

[Discussion] amylin is doing more work than we give it credit for

Discussion

Something I noticed reading old threads that I have not seen said out loud.

The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

171 up / 49 down78% upvoted15 commentsid 1agxc929 Mar 2026

15 comments

12 in this archive, depth 2

best — the order this archive was captured in

u/niels_norgaard28 points·4 months ago

the co-agonism question is real and interesting

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u/noor_hovland8 points·4 months ago

Yeah, amylin is doing different work than GLP-1.

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u/zeynep_zielinski15 points·4 months ago·edited

Strongly agree. REDEFINE is phase 5, not final.

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u/aa_analysis_andy5 points·4 months ago·edited

the mechanism is different, the side effect profile reflects it

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u/hydration_hank7 points·4 months ago

Yeah, amylin is doing different work than GLP-1.

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u/tove_vasquez22 points·4 months ago

long-acting amylin is co-agonism, different satiety profile

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u/rt_shift_reggie10 points·4 months ago

This is correct. The co-agonism is real.

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u/noor_hovland3 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/throwaway_44b19 points·4 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/ferritin_lowOP-33 points·4 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does co-agonism.

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u/slow_logbook_notes304 points·4 months ago

Not convinced. The evidence does not support that reading.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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