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c/cagrilintide·submitted 10 months ago by u/rania_salinas

[Discussion] the cagrilintide advice in here is 21 years out of date

Discussionbranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against eGFR for 37 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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9 comments, started 10 months ago
u/zeynep_zielinski81 points·10 months ago

Strongly agree. REDEFINE is phase 19, not final.

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u/zeynep_duarte43 points·10 months ago

Slight fix: the number was 98.7, not 98.9. Decimal point, but a fairly consequential one.

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u/milos_vestergaard63 points·10 months ago

REDEFINE readouts are phase 2 data

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u/rania_salinasOP45 points·10 months ago

the amylin agonist pool is small, community is satiety

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u/iman_castellanos65 points·10 months ago

long-acting amylin is CagriSema, different satiety profile

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u/viktor_nkemelu17 points·10 months ago

Yeah, amylin is doing different work than GLP-1.

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u/throwaway_44b15 points·10 months ago·edited

long-acting amylin is co-agonism, different satiety profile

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u/rafael_krastev30 points·10 months ago

Strongly agree. REDEFINE is phase 6, not final.

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u/zeynep_ndiaye7 points·10 months ago

CagriSema is a fixed combo in trials, not user-mixed

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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